The Licensing Factor Cdt1 Links Cell Cycle Progression to the DNA Damage Response
Αλεξάνδρα Κανέλλου, Nickolaos Nikiforos Giakoumakis, Ανδρέας Παναγόπουλος, Spyridon Champeris Tsaniras, Zoi Lygerou
Abstract
), and targeted for degradation. We here discuss the cellular functions of Cdt1 and how it may interlink cell cycle regulation and DNA damage response pathways, contributing to genome stability.
Topics & Concepts
DNA replication factor CDT1BiologyGenome instabilityDNA damageOrigin recognition complexDNA re-replicationControl of chromosome duplicationChromatinMinichromosome maintenanceCell biologyEukaryotic DNA replicationDNA replicationCullinLicensing factorCell cycleUbiquitin ligasePre-replication complexReplication factor CGeneticsDNAUbiquitinCellGeneDNA Repair MechanismsUbiquitin and proteasome pathwaysGenomics and Chromatin Dynamics