Enantio- and Diastereoselective Synthesis of P-Stereogenic Phospholane Oxides via Cobalt-Catalyzed Hydroalkylation
Dao‐Yong Zhu, Yating Zhang, Fu Cheng, Qiao Kong, He-Xiang Dang, Hai-Juan Jiao, Ye Zhang, Xiaoming Zhang, Shao‐Hua Wang, Siyao Li
Abstract
Chiral phospholane ligands and catalysts have been widely applied in asymmetric catalysis and synthesis. However, the construction of the chiral phospholane skeleton remains challenging and primarily relies on the use of chiral auxiliaries or resolution. In this work, a highly enantioselective and diastereoselective synthesis of P-stereogenic phospholane oxides has been achieved through a cobalt-catalyzed desymmetric hydroalkylation strategy. This method enables the construction of two discrete stereocenters with excellent yields and enantiomeric excesses.
Topics & Concepts
StereocenterChemistryCatalysisCobaltCombinatorial chemistryOrganic chemistryEnantioselective synthesisAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisOrganophosphorus compounds synthesis