Epidemiology of paraneoplastic neurologic syndromes and autoimmune encephalitides in France
Julien Hébert, Benjamin Riche, Alberto Vogrig, Sergio Muñiz‐Castrillo, Bastien Joubert, Géraldine Picard, Véronique Rogemond, Dimitri Psimaras, Agustí Alentorn, Giulia Berzero, Virginie Desestret, Muriel Rabilloud, Jérôme Honnorat
Abstract
OBJECTIVE: To determine the observed and expected incidence rates of paraneoplastic neurologic syndromes (PNSs) and autoimmune encephalitides (AEs) diagnosed in France between 2016 and 2018, we conducted a population-based epidemiologic study. METHODS: Observed incidence rates were stratified by sex, age groups, region of care, year of diagnosis, and disease subgroups. National expected incidence rates were calculated based on rates obtained in the area directly adjacent to the Reference Center using a mixed Poisson model and compared with observed incidence rates. RESULTS: : 1.0-1.5]) of 2018. CONCLUSIONS: There was a significant widespread year-to-year increase in the incidence of diagnoses registered with the Reference Center for all subgroups of PNS and AE studied. The national observed incidence rate is likely underestimated due to underdiagnosis and underreporting.