Magnetic nanoparticles immobilized thrombin ligand fishing to screen thrombin inhibitors in natural products
Hui Guo, Lili Guo, Jianwei Yu, Fengju Zhao, Wei Yang, Jiaxin Li, Hanqi Chen, Junqing Qian
Topics & Concepts
ChemistryThrombinEnzymeDiscovery and development of direct thrombin inhibitorsChromatographyMangiferinEnzyme assayGlutaraldehydeActive siteBiochemistryBiologyPlateletImmunologyBlood properties and coagulationBlood Coagulation and Thrombosis MechanismsProtease and Inhibitor Mechanisms