Bismuth Drugs Reverse Tet(X)-Conferred Tigecycline Resistance in Gram-Negative Bacteria
Tian Deng, Yuqian Jia, Ziwen Tong, Jingru Shi, Zhiqiang Wang, Yuan Liu
Abstract
Recently, high-level tigecycline resistance mediated by tet (X4) and its variants represents a serious challenge for global public health. Antibiotic adjuvant strategy that enhances the activity of the existing antibiotics by using nonantibiotic drugs offers a distinct approach to combat the antibiotic resistance crisis. In this study, we found that bismuth drugs involve bismuth nitrate, a compound previously approved for treatment of stomach-associated diseases, remarkably potentiates tigecycline activity against tet (X)-positive bacteria.
Topics & Concepts
TigecyclineAntibioticsAntimicrobialMicrobiologyEffluxBacteriaAntibiotic resistanceMultiple drug resistanceBiologyDrug resistancePharmacologyChemistryBiochemistryGeneticsAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsPneumocystis jirovecii pneumonia detection and treatment