Cobalt‐Catalyzed Enantioselective Hydrotrifluoromethoxylation of Aromatic Alkenes
Ya‐Feng Si, Yuntao Liu, Fan Zhou, Lei Fang, Kang Wu, Yu‐Xin Luan, Li Chen, Pingping Tang
Abstract
Abstract The construction of optically pure benzyl trifluoromethoxy (OCF 3 ) compounds continues to present challenges due to limited enantioselectivity‐control or the necessity for OCF 3 ‐containing substrates in the only two previous reports. Herein, we have developed a salen‐Co‐catalyzed enantioselective hydrotrifluoromethoxylation reaction involving aromatic alkenes and trifluoromethyl arylsulfonate (TFMS). This method effectively produces a range of chiral benzyl trifluoromethoxy compounds with enantiomeric excesses ranging from 75% to 99%.
Topics & Concepts
Enantioselective synthesisCatalysisTrifluoromethylEnantiomerCobaltChemistryOptically activeOrganic chemistryCombinatorial chemistryAlkylFluorine in Organic ChemistryInorganic Fluorides and Related Compounds