Targeting granulosa cells with engineered DFO nanoparticles for the treatment of chemotherapy-induced premature ovarian failure
Tuo Zhang, Zhiyi Sheng, Jixian Zhang, Heng Zhang, Yan Zhang, Yan‐Hua Du, Xiangxin Liu, Zhu Hu, Qiyuan Luo, Guoqiang Xu, Yuan Gao, Min He, Tengxiang Chen
Abstract
experiments demonstrate that FSH-mPDA@DFO nanoparticles improve oocyte quantity and quality while restoring fertility and endocrine homeostasis in chemotherapy-induced POF mice. Collectively, FSH-mPDA@DFO nanoparticles hold a great potential for clinical prevention and treatment of POF patients.
Topics & Concepts
Premature ovarian failureChemotherapyOvarian cancerCancer researchMedicinePharmacologyChemistryInternal medicineCell biologyBiologyCancerReproductive Biology and Fertility