Intra-articular metformin-curcumin cationic PLGA nanoparticles rejuvenate articular structure in MIA induced osteoarthritis model via modulating the crosstalk between miR93, TNFAIP3/TLR/NF-κB and AMPK/SIRT1 trajectories
Mennatallah E El-Haddad, Wessam M. El-Refaie, Ghada O Hammad, Magda A. El-Massik
Topics & Concepts
CurcuminMetforminCrosstalkNF-κBAMPKOsteoarthritisChemistryPLGACancer researchCell biologyMedicineApoptosisEndocrinologyDiabetes mellitusBiologyBiochemistryIn vitroPhosphorylationPhysicsPathologyAlternative medicineOpticsProtein kinase AOsteoarthritis Treatment and MechanismsCurcumin's Biomedical ApplicationsChemokine receptors and signaling