Palladium-catalyzed C–P cross-coupling of allenic alcohols with <i>H</i>-phosphonates leading to 2-phosphinoyl-1,3-butadienes
Shanshan Hu, Wenyu Sun, Junhong Chen, Sipei Li, Runmin Zhao, Pengxiang Xu, Yuxing Gao, Yufen Zhao
Abstract
The first facile, efficient, atom-economical and regioselective palladium-catalyzed direct C-P cross-coupling of unprotected allenic alcohols with H-phosphonates for the one-pot synthesis of structurally diverse multisubstituted 2-phosphinoyl-1,3-butadienes was developed. This strategy would enrich the allene chemistry and afford new scaffolds to construct complex molecular skeletons.
Topics & Concepts
PalladiumCatalysisCoupling (piping)ChemistryMedicinal chemistryOrganic chemistryCombinatorial chemistryMaterials scienceMetallurgyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis