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Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer and anti-inflammatory activities

Wael A. A. Fadaly, Mohamed T. M. Nemr, Nesma M. Kahk

2024Bioorganic Chemistry48 citationsDOI

Topics & Concepts

ChemistryThioureaPyrazoleTyrosine kinaseKinaseUreaPharmacologyVEGF receptorsCancer researchCombinatorial chemistryBiochemistryStereochemistrySignal transductionOrganic chemistryMedicineInflammatory mediators and NSAID effectsSynthesis and biological activityCancer, Hypoxia, and Metabolism
Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer and anti-inflammatory activities | Litcius