Long-gap peripheral nerve repair through sustained release of a neurotrophic factor in nonhuman primates
Neil B. Fadia, Jacqueline M. Bliley, Gabriella DiBernardo, Donald J. Crammond, Benjamin K. Schilling, Wesley N. Sivak, Alexander Spiess, Kia M. Washington, Matthias Waldner, Han-Tsung Liao, Isaac B. James, Danielle M. Minteer, Casey Tompkins-Rhoades, Adam Cottrill, Deok‐Yeol Kim, Riccardo Schweizer, Debra Bourne, George E. Panagis, Mark A. Schusterman, Francesco M. Egro, Insiyah Campwala, Tyler W. Simpson, Douglas J. Weber, Trent M. Gause, Jack Brooker, Tvisha Josyula, Astrid A. Guevara, Alexander J. Repko, Christopher M. Mahoney, Kacey G. Marra
Abstract
) treatment groups. This study demonstrates the efficacious bridging of a long peripheral nerve gap in a nonhuman primate model using an acellular, biodegradable nerve conduit.
Topics & Concepts
Nerve growth factorNeurotrophic factorsPeripheral nervePeripheralNeurotrophinMedicineNonhuman primateBrain-derived neurotrophic factorPolycaprolactoneGrowth factorNeuroscienceAnatomyBiologyInternal medicineChemistryReceptorEvolutionary biologyOrganic chemistryPolymerNerve injury and regenerationNeurogenesis and neuroplasticity mechanismsAdvanced Drug Delivery Systems