Engineering the methyltransferase through inactivation of the genK and genL leads to a significant increase of gentamicin C1a production in an industrial strain of Micromonospora echinospora 49-92S
Feng Xu, Xinyu Zhang, Ling Liu, Xiang Ke, Jie Wu, Yuanxin Guo, Xiwei Tian, Ju Chu
Topics & Concepts
Strain (injury)FermentationMutantChemistryGentamicinCitric acid cycleBiochemistryIndustrial and production engineeringFlux (metallurgy)GeneEnzymeAntibioticsBiologyOrganic chemistryElectrical engineeringAnatomyEngineeringMicrobial Metabolic Engineering and BioproductionEnzyme Catalysis and ImmobilizationBacterial Genetics and Biotechnology