The nanobody targeting PD-L1 and CXCR4 counteracts pancreatic stellate cell-mediated tumour progression by disrupting tumour microenvironment
Yaxian Li, Yuejiang Zheng, Shuyi Xu, H. H. Hu, Liyun Peng, Jianwei Zhu, Mingyuan Wu
Topics & Concepts
Pancreatic cancerTumor microenvironmentCancer researchStromal cellHepatic stellate cellImmune systemPI3K/AKT/mTOR pathwayEpithelial–mesenchymal transitionCXCR4MetastasisChemistryBiologySignal transductionMedicineCancerImmunologyPathologyCell biologyChemokineInternal medicineTumor cellsPancreatic and Hepatic Oncology ResearchCancer Cells and MetastasisCancer Immunotherapy and Biomarkers