Fluorescent-pigmented Microbial Polymer Nanoparticles: an Approach for Replacement of Bioimaging Agent in the Drug Delivery System
Ksheerabdi Tanaya, Swati Mohapatra, S. Maity, Deviprasad Samantaray
Abstract
Abstract Currently, nanomaterials are getting more attention in drug delivery system (DDS), due to its flexibility in terms of physical, mechanical, electrical, magnetic, chemical and biological nature to achieve the higher therapeutic effects of a pharmaceutical drug. DDS is comprised of 3 major components including drug delivery carrier like polymer, therapeutic drug and an imaging agent. Biocompatible biopolymers polyhydroxyalkanoates (PHAs) are recognized as potential drug delivery carrier for transportation of drug along with imaging agent to the target site. Optical imaging agents such as fluorescent organic dyes, quantum dots, gold and silver nanoparticles are used for image-guided therapy in DDS. However, their cytotoxicity, carcinogenicity, mutagenicity, immunogenicity, reduced illumination and photostability holds back its successful application in human trails. Herein we put forth our hypothetical views for usage of fluorescent-pigmented PHAs nanoparticle in DDS and replace conventional imaging agents to resolve versatile issues concerned with these agents. Further, extensive research is highly essential prior to its applications.