FKBP4 is a malignant indicator in luminal A subtype of breast cancer
Hanchu Xiong, Zihan Chen, Wenwen Zheng, Jing Sun, Qingshuang Fu, Rongyue Teng, Jida Chen, Shuduo Xie, Linbo Wang, Xiao‐Fang Yu, Jichun Zhou
Abstract
Purpose: FKBP4 is a member of the immunophilin protein family, which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking associated with HSP90. However, the relationship between abnormal expression of FKBP4 and clinical outcome in luminal A subtype breast cancer (LABC) patients remains to be elucidated. Methods: Oncomine, bc-GenExMiner and HPA database were used for data mining and analyzing FKBP4 and its co-expressed genes. GEPIA database was used for screening co-expressed genes of FKBP4. Results: For the first time, we found that higher FKBP4 expression correlated with LABC patients and worse survival. Moreover, the upregulated co-expressed genes of FKBP4 were assessed to be significantly correlated with worse survival in LABC, and might be involved in the biological role of FKBP4.