Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer
Junfeng Zhang, Jian‐Yu Yang, Chaoyi Lin, Wei Liu, Yan‐Miao Huo, Minwei Yang, Shu‐Heng Jiang, Yongwei Sun, Rong Hua
Abstract
Our findings uncover a key function for ERO1L in Warburg metabolism and indicate that targeting this pathway may offer alternative therapeutic strategies for PDAC.
Topics & Concepts
Endoplasmic reticulumPancreatic cancerGlycolysisUnfolded protein responseAnaerobic glycolysisCell biologyChemistryStress (linguistics)Cancer researchCancerEndocrinologyBiologyMedicineInternal medicineBiochemistryMetabolismPhilosophyLinguisticsCancer, Hypoxia, and MetabolismEndoplasmic Reticulum Stress and DiseaseMitochondrial Function and Pathology