Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil
Bingxue Yang, Xinran Xie, Dazhao Lv, Jiajun Hu, Yuyun Chen, Zhaoyu Wu, Shuyue Luo, Shiyi Zhang
Topics & Concepts
CapecitabineThymidine phosphorylaseToxicityPharmacologyCytotoxicityChemistryMetaboliteCancer researchIn vitroInternal medicineMedicineBiochemistryCancerEnzymeColorectal cancerChemotherapy-related skin toxicityColorectal Cancer Treatments and StudiesChemotherapy-induced cardiotoxicity and mitigation