Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function
Vera-Marie E. Dunlock, Abbey B. Arp, Simar Pal Singh, Stéphanie Charrin, Việt Hùng Nguyễn, Erik W.L. Jansen, Fleur Schaper, Martin ter Beest, Malou Zuidscherwoude, Sjoerd J. van Deventer, Britt Nakken, Péter Szodoray, Maria C. Demaria, Mark D. Wright, Laia Querol Cano, Eric Rubinstein, Annemiek B. van Spriel
Abstract
mice show impaired tumor rejection and reduced IFNγ-producing T cells compared with wild-type mice. Investigation into the mechanism reveals that CD53 is required for CD45RO expression and mobility. In addition, CD53 is shown to stabilize CD45 on the membrane and is required for optimal phosphatase activity and subsequent Lck activation. Together, our findings reveal CD53 as a regulator of CD45 activity required for T cell immunity.
Topics & Concepts
TetraspaninCell biologyT cellFunction (biology)RegulatorPhosphataseReceptorBiologyCellChemistryMolecular biologyImmune systemImmunologyPhosphorylationBiochemistryGeneT-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses