Modern approaches towards the synthesis of geminal difluoroalkyl groups
Dayanne R. Carvalho, Alec H. Christian
Abstract
This review will cover the importance of and most recent approaches toward geminal difluoroalkyl groups. Transition metal-mediated, photochemical, organocatalytic, and other methods as well as their mechanistic implications will be discussed, with special emphasis on applications to biologically-relevant compounds.
Topics & Concepts
GeminalCover (algebra)ChemistryComputational chemistryOrganic chemistryEngineeringMechanical engineeringFluorine in Organic ChemistrySynthesis and Reactions of Organic CompoundsInorganic Fluorides and Related Compounds