Structure and inhibition mechanism of some synthetic compounds and phenolic derivatives as tyrosinase inhibitors: review and new insight

Abstract

and their binding energy. Further, inhibition mechanism and the biological effects of some these inhibitors with potential application in food, agricultural, cosmetic and pharmaceutical industries were briefly discussed. Molecular docking procedure was performed on some derivatives and demonstrated favorable binding affinity with amino acid residues of mushroom tyrosinase (PDB ID: 2Y9X). The information offered showed that the substitution pattern of hydroxyl groups at the phenyl ring is an important factor of tyrosinase inhibitory activity. The results confirmed that understanding structural modification of inhibitors is a key role in finding novel and efficacious tyrosinase inhibitors.Communicated by Ramaswamy H. Sarma.

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