Oral Microbiota from Periodontitis Promote Oral Squamous Cell Carcinoma Development via γδ T Cell Activation
Wei Wei, Jia Li, Xin Shen, Jinglu Lyu, Caixia Yan, Boyu Tang, Wenjuan Ma, Huixu Xie, Леи Жао, Lei Cheng, Ye Deng, Yan Li
Abstract
The work reveals the role of the oral microbiota from periodontitis in carcinogenesis. Furthermore, our study provides insight into the pathogenesis of OSCC with periodontitis by outlining the tumor-associated immune response shaped by the oral microbiota from periodontitis, which might identify new research and intervention targets for OSCC with periodontitis.
Topics & Concepts
PeriodontitisBasal cellCarcinogenesisChronic periodontitisOral CancersImmune systemPathogenesisMedicineInflammationImmunologyBiologyCancer researchDentistryPathologyCancerInternal medicineOral microbiology and periodontitis researchOral Health Pathology and TreatmentImmune Response and Inflammation