Access to spiro-bicyclo[2.1.1]hexanes <i>via</i> BF <sub>3</sub> ·Et <sub>2</sub> O-catalyzed formal [2π + 2σ] cycloaddition of bicyclo[1.1.0]butanes with benzofuran-derived oxa(aza)dienes
Jia-Yi Su, Jian Zhang, Zhiyun Xin, Hao Li, Hanliang Zheng, Wei‐Ping Deng
Abstract
Rapid access to diverse spiro[benzofuran-2,2′-bicyclo[2.1.1]hexanes] via BF 3 ·Et 2 O-catalyzed [2π + 2σ] cycloaddition of bicyclo[1.1.0]butanes with readily available benzofuran-derived oxa(aza)dienes.
Topics & Concepts
Bicyclic moleculeCycloadditionChemistryBenzofuranCatalysisMedicinal chemistryStereochemistryOrganic chemistryOxidative Organic Chemistry ReactionsCyclopropane Reaction MechanismsSynthetic Organic Chemistry Methods