Preliminary pre-clinical studies on the side effects of breast cancer treatment
Camila Salata, Carlos Eduardo de Almeida, Samara Cristina Ferreira-Machado, R.C. Barroso, Liebert Parreiras Nogueira, Andrea Mantuano, Arissa Pickler, Carla Lemos Mota, Cherley Borba Vieira de Andrade
Abstract
Radiation-induced heart disease is one important side effect that must be considered during the treatment planning and patient follow-up. The cardiac damage can be potentialized when chemotherapy is associated to radiotherapy, and the literature findings indicate that heart fibrosis plays an important role at the radio-chemotherapy induced cardiac damage. Literature findings also showed important side effects at the bone, that can lead to ospeoporosis, due to the decrease of calcium, after radio or chemotherapy treatments. This decrease could be explained by the ovarian failure observed at rats after chemotherapy treatment. It is of great importance to acknowledge the complications originating from the treatment, so that new strategies can be developed. In this way, it will be possible to minimize side effects and improve the patients' quality of life.