Matrix metalloproteinase responsive hydrogel microplates for programmed killing of invasive tumour cells
Alexander Cook, Anna Lisa Palange, Michele Schlich, Elena Bellotti, Sayanti Brahmachari, Martina Di Francesco, Paolo Decuzzi
Abstract
Hydrogel microplates are formed through photoinitiated thiol–ene chemistry in a soft-lithography process, leading to enzyme responsive drug nanoparticle release to MMP-2/9 expressing brain cancer cell line U87-MG.
Topics & Concepts
Self-healing hydrogelsChemistryPeptidePLGANanoparticleBiophysicsPolyethylene glycolMaterials scienceNanotechnologyPolymer chemistryBiochemistryBiologyNanoparticle-Based Drug Delivery3D Printing in Biomedical ResearchElectrospun Nanofibers in Biomedical Applications