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Direct observation and control of non-classical crystallization pathways in binary colloidal systems

Shihao Zang, Sanjib Paul, Cheuk Wai Leung, Michael S. Chen, Theodore Hueckel, Glen M. Hocky, Stefano Sacanna

2025Nature Communications18 citationsDOIOpen Access PDF

Abstract

Crystallization stands as a prime example of self-assembly. Elementary building blocks converge, seemingly adhering to an intricate blueprint, orchestrating order from chaos. While classical theories describe crystallization as a monomer-by-monomer addition, non-classical pathways introduce complexity. Using microscopic charged particles as monomers, we uncover the mechanisms governing the formation of ionic colloidal crystals. Our findings reveal a two-step process, wherein metastable amorphous blobs condense from the gas phase, before evolving into small binary crystals. These small crystals then grow into large faceted structures via three simultaneous processes: addition of free monomers from bulk, capture and absorption of surrounding blobs, and oriented attachment of other crystals. These complex crystallization pathways occur both in bulk and on surfaces across a range of particle sizes and interaction strengths, resulting in a diverse array of crystal types and morphologies. Harnessing our ability to tune the interaction potential through small changes in salt concentration, we developed a continuous dialysis approach that allows fine control over the interaction strength in both time and space. This method enables us to discover and characterize various crystal structures in a single experiment, including a previously unreported low-density hollow structure and the heteroepitaxial formation of composite crystal structures. This study reveals how ionic colloidal crystals form through a two-step process, where amorphous blobs condense before transforming into ordered structures. By tuning interactions via continuous dialysis, researchers uncovered new crystal types, including a previously unknown open-framework structure.

Topics & Concepts

CrystallizationBinary numberColloidComputer scienceComputational biologyNanotechnologyMaterials scienceChemistryBiologyPhysicsMathematicsThermodynamicsPhysical chemistryArithmeticCrystallization and Solubility StudiesCalcium Carbonate Crystallization and InhibitionChemical and Physical Properties in Aqueous Solutions
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