Radical-induced denitration of <i>N</i>-(<i>p</i>-nitrophenyl)propiolamides coupled with dearomatization: access to phosphonylated/trifluoromethylated azaspiro[4.5]-trienones
Kangdong Mo, Xiaocong Zhou, Ju Wu, Yufen Zhao
Abstract
-cyclization process has been developed, delivering valuable phosphonated or trifluoromethylated azaspiro[4.5]trienones with good functional group tolerance. This represents a convenient and powerful approach to activate nitroarenes in a radical manner.
Topics & Concepts
ChemistryRadical cyclizationFunctional groupRadicalCombinatorial chemistryMedicinal chemistryOrganic chemistryPolymerRadical Photochemical ReactionsFluorine in Organic ChemistrySulfur-Based Synthesis Techniques