Amantadine and Rimantadine Inhibit Hepatitis A Virus Replication through the Induction of Autophagy
Reina Sasaki, Toshikatsu Shibata, Mitsuhiko Moriyama, Hiroaki Okamoto, Hirofumi Kogure, Tatsuo Kanda
Abstract
Amantadine, a nonspecific antiviral medication, also effectively inhibits HAV replication. Autophagy is an important cellular mechanism in several virus-host cell interactions. The results of this study provide evidence indicating that autophagy is involved in HAV replication and plays a role in the HAV life cycle. In addition, amantadine and its derivative rimantadine suppress HAV replication partly by enhancing autophagy at the post-entry phase of HAV infection in human hepatocytes. Amantadine may be useful for the control of acute HAV infection by inhibiting cellular autophagy pathways during HAV infection processes.
Topics & Concepts
RimantadineAmantadineBiologyVirologyViral replicationAutophagyVirusReplication (statistics)Influenza A virusHepatitis C virusGeneticsApoptosisAutophagy in Disease and TherapyHepatitis C virus researchCannabis and Cannabinoid Research