Cp*Rh(III)-Catalyzed ortho-Alkylation/Alkenylation of Nitroarenes
Lin Xiao, Xu‐Ge Liu, Mei-Zhu Bao, Jia‐Lin Song, Shaoyong Chen, Yi‐Chuan Zheng, Yanzhi Liu, Shang‐Shi Zhang
Abstract
Cp*Rh(III)-catalyzed nitro-directed C-H alkylation/alkenylation of nitroarenes has been reported for the first time. This protocol is associated with the features of high efficiency, broad substrate scope, and good functional group compatibility. Additionally, gram-scale experiments and synthetic applications proved the practicability of the method. Moreover, preliminary mechanistic investigations consistently revealed C-H bond cleavage as the rate-limiting step.
Topics & Concepts
ChemistryAlkylationCatalysisCombinatorial chemistryCompatibility (geochemistry)NitroFunctional groupLimitingBond cleavageCleavage (geology)Medicinal chemistryStereochemistryOrganic chemistryChemical engineeringGeotechnical engineeringPolymerFracture (geology)EngineeringMechanical engineeringAlkylCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthesis and Catalytic Reactions