Chemically engineering cells for precision medicine
Yixin Wang, Zhaoting Li, Fanyi Mo, Ting‐Jing Chen‐Mayfield, Aryan Saini, Afton Martin LaMere, Quanyin Hu
Abstract
trafficking and lack of therapeutic payloads. Chemical engineering offers a cost-effective, easy-to-implement engineering tool that allows for strengthening the inherent favorable features of cells and confers them new functionalities. Moreover, in accordance with the trend of precision medicine, leveraging chemical engineering tools to tailor cells to accommodate patients individual needs has become important for the development of cell-based treatment modalities. This review presents a comprehensive summary of the currently available chemically engineered tools, introduces their application in advanced diagnosis and precision therapy, and discusses the current challenges and future opportunities.