Role of interferon regulatory factor-mediated signaling in psoriasis
Wenming Wang, Li Feng, Hongzhong Jin
Abstract
Psoriasis is a chronic inflammatory disease that involves both the innate and adaptive immune systems. Type I interferons (IFNs), the production of which is partially regulated by toll-like receptors (TLRs), play an important role in the pathogenesis of psoriasis, especially psoriasis caused by skin trauma, known as the Koebner phenomenon. IFN regulatory factors (IRFs) function in both innate and adaptive immune responses, and their effect is associated with the regulation of type I IFNs. In this review, we focus on recent advances in understanding the expression of TLRs, IRFs, and type I IFNs in psoriasis. We also highlight the interplay among TLRs, IRFs, and type I IFNs.
Topics & Concepts
PsoriasisImmunologyPathogenesisInnate immune systemImmune systemInterferon regulatory factorsInterferonAcquired immune systemBiologyToll-like receptorFunction (biology)Cell biologyPsoriasis: Treatment and PathogenesisCytokine Signaling Pathways and InteractionsImmune Response and Inflammation