A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization
William T. Yewdell, Youngjun Kim, Priyanka Chowdhury, Colleen M. Lau, Ryan Smolkin, Kalina T. Belcheva, Keith Conrad Fernandez, Montserrat Cols, Wei-Feng Yen, Bharat Vaidyanathan, Davide Angeletti, Adrian B. McDermott, Jonathan W. Yewdell, Joseph C. Sun, Jayanta Chaudhuri
Topics & Concepts
Somatic hypermutationActivation-induced (cytidine) deaminaseCytidine deaminaseBiologyImmunoglobulin class switchingChromatinGerminal centerGeneMutationAffinity maturationGeneticsMolecular biologyGenomeB cellAntibodyT-cell and B-cell ImmunologyCytomegalovirus and herpesvirus researchImmune Cell Function and Interaction