Discovery of<i>N</i>-(1-(3-fluorobenzoyl)-1<i>H</i>-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B
Ahmed Elkamhawy, Sora Paik, Hyeon Jeong Kim, Jong Hyun Park, Ashwini M. Londhe, Kyeong Lee, Ae Nim Pae, Ki Duk Park, Eun Joo Roh
Abstract
-indol-5-yl)pyrazine-2-carboxamide), with its selectivity and competitive inhibition, advocates its potential role as a promising lead worthy of further optimization.
Topics & Concepts
ChemistryPyrazineIndazoleSelectivityIndole testIC50CarboxamideStereochemistryMonoamine oxidaseNon-competitive inhibitionLead compoundPhthalazineMonoamine oxidase BRasagilineDocking (animal)Medicinal chemistryEnzymeIn vitroBiochemistryParkinson's diseaseDiseaseNursingCatalysisPathologyMedicineSynthesis and Biological EvaluationClick Chemistry and ApplicationsAdenosine and Purinergic Signaling