Thyme (<i>Thymus vulgaris</i> L.) polyphenols ameliorate DSS-induced ulcerative colitis of mice by mitigating intestinal barrier damage, regulating gut microbiota, and suppressing TLR4/NF-κB-NLRP3 inflammasome pathways
Zuman Zhou, Wanying He, Honglei Tian, Ping Zhan, Jianshu Liu
Abstract
associated with the inflammatory process were significantly inhibited. Notably, TP supplemented at the dose of 100 mg per kg bw showed weak mitigated effects on the above symptoms, while the other two TP experimental groups showed similar promising therapeutic potential, suggesting that such beneficial effects required a certain dose of TP to be achieved. These results indicated that TP could suppress the TLR4/NLRP3-NF-κB inflammasome pathways, protect the intestinal epithelial barrier, and remodel the disordered gut microbiota, which suggested that TP might be a promising dietary strategy for UC.
Topics & Concepts
Rosmarinic acidChemistryColitisCaffeic acidInflammasomeGut floraSulfasalazinePharmacologyGallic acidBiochemistryUlcerative colitisBiologyAntioxidantImmunologyMedicineReceptorPathologyDiseaseGut microbiota and healthInflammatory Bowel DiseaseNatural product bioactivities and synthesis