Multiresistance to Nonazole Fungicides in Aspergillus fumigatus TR <sub>34</sub> /L98H Azole-Resistant Isolates
Irene González-Jiménez, Rocio Garcia‐Rubio, Sara Monzón, J. L. Lucio, Isabel Cuesta, Emilia Mellado
Abstract
conferred resistance to QoIs, and H270R/Y mutations in SdhB conferred resistance to SDHIs. Characterization of susceptibility to azoles showed a correlation between strains resistant to these fungicides and the ones with tandem-repeat (TR)-based azole resistance mechanisms. Whole-genome sequencing analysis showed a genetic relationship among fungicide multiresistant strains, which grouped into subclusters that included only strains carrying the TR-based azole resistance mechanisms, indicating a common ancestor/evolution pattern and confirming the environmental origin of this type of azole-resistant A. fumigatus.
Topics & Concepts
Aspergillus fumigatusAzoleBiologyFungicideMicrobiologyCross-resistanceDrug resistanceAntifungalBotanyFungal Plant Pathogen ControlAntifungal resistance and susceptibilityPlant Pathogens and Fungal Diseases