Enantioselective aerobic oxidative cross-dehydrogenative coupling of glycine derivatives with ketones and aldehydes <i>via</i> cooperative photoredox catalysis and organocatalysis
Xiaorong Yang, Zhixiang Xie, Ying Li, Yuan Zhang
Abstract
from a ketone or aldehyde and a chiral secondary amine organocatalyst. This mild method allows the direct formation of a C-C bond with simultaneous installation of two new stereocenters without wasteful removal of functional groups.
Topics & Concepts
Enantioselective synthesisOrganocatalysisGlycineChemistryOxidative phosphorylationPhotoredox catalysisCatalysisOxidative coupling of methaneCombinatorial chemistryOrganic chemistryAmino acidPhotocatalysisBiochemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions