Reusable Brønsted Acidic Ionic Liquid Efficiently Catalyzed <i>N</i>-Formylation and <i>N</i>-Acylation of Amines
Chun Li, Mengna Wang, Xunhua Lu, Ling Zhang, Ling Zhang, Jian Jiang, Lin Zhang, Lin Zhang
Abstract
We disclose efficient and green N-formylation and N-acylation methodologies of various amines with carboxylic acids for the synthesis of versatile amides in the presence of Brønsted acidic ionic liquid. Furthermore, the N-formylation and N-acylation with DMF and DMA have also been achieved in the same catalytic system. Notably, the catalyst in this catalytic solvent-free protocol could be easily recycled for up to five consecutive cycles with slight loss of activity.
Topics & Concepts
FormylationAcylationIonic liquidCatalysisChemistryOrganic chemistrySolventOrganocatalysisCombinatorial chemistryEnantioselective synthesisCarbon dioxide utilization in catalysisChemical Synthesis and ReactionsChemical Synthesis and Analysis