Multicomponent-Loaded Vesosomal Drug Carrier for Controlled and Sustained Compound Release
Deborah Lee, Seoyoon Song, Suheon Kim, Suheon Kim, Mina Lee, Eunsu Kim, Sunhee Yoon, Han‐ul Kim, Sejin Son, Hyun Suk Jung, Yun Suk Huh, Sun Min Kim, Sun Min Kim, Tae‐Joon Jeon
Abstract
Liposomes have been extensively adopted in drug delivery systems with clinically approved formulations. However, hurdles remain in terms of loading multiple components and precisely controlling their release. Herein, we report a vesosomal carrier composed of liposomes encapsulated inside the core of another liposome for the controlled and sustained release of multiple contents. The inner liposomes are made of lipids with different compositions and are co-encapsulated with a photosensitizer. Upon induction of reactive oxygen species (ROS), the contents of the liposomes are released, with each type of liposome displaying distinct kinetics due to the variance in lipid peroxidation for differential structural deformation. In vitro experiments demonstrated immediate content release from ROS-vulnerable liposomes, followed by sustained release from ROS-nonvulnerable liposomes. Moreover, the release trigger was validated at the organismal level using Caenorhabditis elegans . This study demonstrates a promising platform for more precisely controlling the release of multiple components.