S-acylation modulates the function of the apical sodium-dependent bile acid transporter in human cells
Alexander L. Ticho, P.K. Malhotra, Christopher R. Manzella, Pradeep K. Dudeja, Seema Saksena, Ravinder K. Gill, Waddah A. Alrefai
Abstract
-acylation is involved in the modulation of ASBT function. These findings underscore the potential for unsaturated fatty acids to reduce ASBT function, which may be useful in disorders in which bile acid toxicity is implicated.
Topics & Concepts
TransporterAcylationFunction (biology)ChemistryCell biologyBiochemistrySymporterBile acidSodiumBiologyGeneOrganic chemistryCatalysisDrug Transport and Resistance MechanismsIon Transport and Channel RegulationAdenosine and Purinergic Signaling