On the Structure of Intermediates in Enyne Gold(I)‐Catalyzed Cyclizations: Formation of <i>trans</i>‐Fused Bicyclo[5.1.0]octanes as a Case Study
Imma Escofet, Helena Armengol‐Relats, Hanna Bruss, María Besora, Antonio M. Echavarren
Abstract
The nature of cyclopropyl gold(I) carbene-type intermediates has been reexamined as part of a mechanistic study on the formation of cis- or trans-fused bicyclo[5.1.0]octanes in a gold(I)-catalyzed cascade reaction. Benchmark of DFT methods together with QTAIM theory and NBO analysis confirms the formation of distinct intermediates with carbenic or carbocationic structures in the cycloisomerizations of enynes.
Topics & Concepts
Bicyclic moleculeEnyneCatalysisChemistryStereochemistryMedicinal chemistryOrganic chemistryCatalytic Alkyne ReactionsCatalysis and Hydrodesulfurization StudiesSynthetic Organic Chemistry Methods