Chronic Inhibition of mROS Protects Against Coronary Endothelial Dysfunction in Mice With Diabetes
Hang Xing, Zhiqi Zhang, Guangbin Shi, Yixin He, Yi Song, Yuhong Liu, Elizabeth O. Harrington, Frank W. Sellke, Jun Feng
Abstract
< 0.05). Interestingly, coronary relaxation responses to ADP and NS309 and endothelial SK channel currents were not significantly changed in ND mice after mito-Tempo treatment, as compared to that of untreated control group. Chronic inhibition of endothelial mROS appears to improve coronary endothelial function/dilation and SK channel activity in diabetes, and mROS inhibitors may be a novel strategy to treat vascular complications in diabetes.
Topics & Concepts
Endothelial dysfunctionAntioxidantEndotheliumMedicineOxidative stressReactive oxygen speciesDiabetes mellitusEndothelial stem cellInternal medicinePharmacologyNitric oxideEndocrinologyChemistryBiochemistryIn vitroNitric Oxide and Endothelin EffectsEicosanoids and Hypertension PharmacologyMitochondrial Function and Pathology