Tumor-associated macrophage enhances PD-L1-mediated immune escape of bladder cancer through PKM2 dimer-STAT3 complex nuclear translocation
Yongbo Yu, Ye Liang, Fei Xie, Zhao Zhang, Pengfei Zhang, Xinzhao Zhao, Zhilei Zhang, Zhijuan Liang, Dan Li, Liping Wang, Yuanbin Chen, Lijiang Sun, Haitao Niu, Yonghua Wang, Yonghua Wang
Topics & Concepts
PKM2Cancer researchTumor microenvironmentImmune checkpointImmune systemBiologySTAT3ImmunotherapyPD-L1STAT proteinSignal transductionCell biologyPyruvate kinaseImmunologyGlycolysisBiochemistryEnzymeImmune cells in cancerEpigenetics and DNA MethylationCancer, Hypoxia, and Metabolism