HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses
Clare Burn Aschner, Lip Nam Loh, Benjamin Galen, Isabel Delwel, Rohit K. Jangra, S. Garforth, Kartik Chandran, Steven C. Almo, William R. Jacobs, Carl F. Ware, Betsy C. Herold
Abstract
mice were impaired in FcγR activation, and, conversely, addition of gD protein or anti-HVEM antibodies to in vitro murine or human FcγR activation assays inhibited the response. These findings uncover a previously unrecognized role for HVEM signaling in generating and mediating ADCC and an additional HSV immune evasion strategy.
Topics & Concepts
Antibody-dependent cell-mediated cytotoxicityHerpes simplex virusVirologyCytotoxicityAntibodyBiologyVirusImmunologyIn vitroMonoclonal antibodyBiochemistryHerpesvirus Infections and TreatmentsVirus-based gene therapy researchAnimal Virus Infections Studies