Tenofovir antiviral drug solubility enhancement with β-cyclodextrin inclusion complex and in silico study of potential inhibitor against SARS-CoV-2 main protease (Mpro)
Sonaimuthu Mohandoss, Kuppu Sakthi Velu, Stalin Thambusamy, Naushad Ahmad, Suliman Yousef Alomar, Yong Rok Lee
Topics & Concepts
SolubilityChemistryProteaseProtease inhibitor (pharmacology)CyclodextrinIn silicoCombinatorial chemistryChromatographyEnzymeBiochemistryOrganic chemistryVirusVirologyBiologyViral loadGeneAntiretroviral therapyComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 ResearchDrug-Induced Hepatotoxicity and Protection