Some Chloroquine Derivatives for Promising New Antifungal Drugs and Absorption Behavior
Rana A. K. Al-Refai’a, Karar Abdali, Ehssan Al‐Bermany
Abstract
Chloroquine (CQ) has been a good treatment for antimalarial mainstay for several decades; additionally discovered, it has a significant therapeutic impact on some instances of fungal inhibition. This study focused on the effect of novel CQ compounds on the activity of two different species of fungi, Aspergillus niger and Aspergillus falves. The activity of each CQ derivative was monitored using Nuclear magnetic resonance spectroscopy (NMR), minimal inhibitory concentration and physical parameters such as optical microscopy, UV/visible absorbance and optical band gap. NMR indicated the conjugation between the substrate and amino acid. The optical microscopic images indicated homogeneously distributed and uniform density distribution of CQ-derivative particles on the glass substrates. The samples’ presented absorption peaks at 203, 207 and 220 nm wavelengths, suggesting the important electronic transition with reducing the indirect bandgap from 4.1 eV to 3.95 eV. These compounds have the best antifungal growth inhibitory properties and excellent features, indicating cosmetics use.