Cyclic natural product oligomers: diversity and (bio)synthesis of macrocycles
Songya Zhang, Shuai Fan, Haocheng He, Haocheng He, Jing Zhu, Lauren A. M. Murray, Gong Liang, Ran Shi, Yi Zhu, Max J. Cryle, Haiyan He, Haiyan He, You‐Ming Zhang
Abstract
-mediated cyclization of peptides, alongside the formation of cyclodipeptides mediated by cyclodipeptide synthases (CDPS) and single-module NRPSs. Due to the interdisciplinary nature of biosynthetic research, we anticipate that this review will prove valuable to synthetic chemists, drug discovery groups, enzymologists, and the biosynthetic community in general, and inspire further efforts to identify and exploit these biocatalysts for the formation of novel bioactive molecules.
Topics & Concepts
Natural productChemistryMetathesisCycloadditionDisulfide bondRing-closing metathesisEnzymeCombinatorial chemistryRing (chemistry)Organic chemistryStereochemistryBiochemistryPolymerizationCatalysisPolymerCarbohydrate Chemistry and SynthesisMicrobial Natural Products and BiosynthesisEnzyme Catalysis and Immobilization