A platform for the rapid synthesis of proteolysis targeting chimeras (Rapid-TAC) under miniaturized conditions
Le Guo, Yaxian Zhou, Xueqing Nie, Zhongrui Zhang, Zhen Zhang, Chunrong Li, Taobo Wang, Weiping Tang
Topics & Concepts
ChemistryLinkerDrug discoveryUbiquitin ligaseDNA ligaseCombinatorial chemistryChimera (genetics)ProteolysisTarget proteinLigand (biochemistry)Protein degradationComputational biologyNanotechnologyStereochemistryBiochemistryUbiquitinReceptorDNABiologyComputer scienceMaterials scienceGeneEnzymeOperating systemProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments