Novel aromatic moieties-modified poly(glycidyl amine)s with potent siRNA delivery and cancer treatment effect
Qi Shuai, Wanxuan Xie, Siyuan Chen, Huahui Su, Yunfeng Yan
Abstract
efficacy of the selected NPs was further validated by a remarkable anti-cancer effect when employed for the delivery of siRNA targeting polo-like kinase 1 (siPLK1) to mice with PC-3 xenograft tumors. The intravenous administration of NPs resulted in a substantial inhibition of tumor growth without significant toxicity. These findings demonstrate the feasibility of employing PGAm in siRNA delivery and provide valuable insights for the development of efficient siRNA carriers based on PGAm.
Topics & Concepts
Amine gas treatingGlycidyl methacrylateCombinatorial chemistryMaterials scienceNanotechnologyChemistryOrganic chemistryPolymerPolymerizationRNA Interference and Gene DeliveryGraphene and Nanomaterials ApplicationsAdvanced biosensing and bioanalysis techniques