Allogeneic CAR T cells for autoimmune diseases: a glimpse into the future
Dimitrios Mougiakakos
Abstract
In a recent study published in Cell , Wang X et al. 1 reported the first use of allogeneic anti-CD19 CAR T cells in patients with therapy-resistant autoimmune diseases, demonstrating their effectiveness in reducing disease activity, with good tolerability and persistence. These findings suggest that allogeneic CAR T cells could offer a scalable, off-the-shelf treatment option for autoimmune disorders.
Topics & Concepts
ImmunologyMedicineComputational biologyBiologyCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in InsectsT-cell and B-cell Immunology