Phospholipid metabolites of the gut microbiota promote hypoxia-induced intestinal injury via CD1d-dependent γδ T cells
Yuyu Li, Yuchong Wang, Fan Shi, Xujun Zhang, Yongting Zhang, Kefan Bi, Xuequn Chen, Lanjuan Li, Hongyan Diao
Abstract
are presented by intestinal epithelial CD1d to induce the proliferation of IL-17A-producing γδ T cells, which aggravates intestinal injury. Gut microbiota-derived metabolites promote hypoxia-induced intestinal injury via CD1d-dependent γδ T cells, suggesting that phospholipid metabolites and γδ T cells can be targets for AMS therapy.
Topics & Concepts
Gut floraBiologyHypoxia (environmental)Intestinal mucosaCD1DIntraepithelial lymphocyteMicrobiologyImmunologyT cellImmune systemInternal medicineT-cell receptorChemistryMedicineOrganic chemistryOxygenImmune Response and InflammationGut microbiota and healthImmune Cell Function and Interaction