<i>In Vitro</i> and <i>In Vivo</i> Antimicrobial Activity of Hypochlorous Acid against Drug-Resistant and Biofilm-Producing Strains
Marta Palau, Estela Muñoz, Enric Lujan, Nieves Larrosa, Xavier Gomis, Ester Márquez‐Algaba, Óscar Len, Benito Almirante, Jordi Abellà, Sergi Colominas, Joan Gavaldà
Abstract
Currently, drug-resistant infections are increasing and there are fewer antibiotics available to treat them. Therefore, there is an urgent need to find new antibiotics and nonantimicrobial strategies to treat these infections. We present a new nonantibiotic strategy based on hypochlorous acid generation to treat long-term catheter-related and chronic wounds infections.
Topics & Concepts
BiofilmHypochlorous acidIn vivoAntimicrobialIn vitroMicrobiologyDrugChemistryAntimicrobial drugPharmacologyBiologyBacteriaBiochemistryBiotechnologyGeneticsBacterial biofilms and quorum sensingWater Treatment and DisinfectionLegionella and Acanthamoeba research